2009年4月28日 星期二

人类大流感回顾

时事风云 | 2009.04.28

人类大流感回顾

随着猪流感疫情的进一步蔓延,世界卫生组织已经将猪流感的警戒级别调高至第四级,该组织总干事陈冯富珍表示,猪流感病毒有在全球广泛爆发的可能性。专家指 出,当一种新型的病毒广泛传播,而大多数人还不具备抵抗这种新病毒的自然免疫力时,全球性的瘟疫就会爆发。至少从16世纪起,各种流感瘟疫就一直在以不规 律的间歇不断爆发。

世 界卫生组织宣布,北美爆发的猪流感疫情构成了国际关注的突发公共卫生事件,并将目前人类大流感警戒级别从第三级调高到第四级,即出现病毒在人与人之间持续 传播的阶段。人类大流感警戒级别共分为六级,世界卫生组织表示,把警戒级别调高到第四级意味着出现人类大流感的可能性增加了,但并不是不可避免。

在 过去的一个世纪里,全球性的流感瘟疫,也就是世界卫生组织所说的人类大流感,一共出现过至少五次。1918年至1919年爆发了被称为"史上最恐怖的流 感"--西班牙流感,这种病毒也是H1N1型病毒的一个种类,主要袭击青壮年,当时造成了全球大约20%到40%的人口感染,死亡人数至少有4千万到5千 万,是一战死亡人数的差不多五倍。这种病毒最早是在美国发现的,但是之所以得名"西班牙病毒",是因为当时的西班牙媒体对这种瘟疫投入了大量的精力报道, 而在第一次世界大战期间,许多其它国家的媒体处于严密的监控之下,无法进行自由报道。

20世纪的第二次大型全球性流感,是1957年爆发的所谓亚洲流感。这种流感病毒属于H2N2型病毒,最早在中国发现。该流感病毒早期感染的是儿童,后来则主要袭击老年人。这一波亚洲流感造成全球大约2百万人死亡。

1968年爆发的香港流感是上世纪疫情最轻的一次人类大流感。这种H3N2型流感病毒最早出现于香港,之后在接下来的两年中扩散到全世界。患病者主要是老年人,全球死亡人数大约为一百万。

进 入21世纪之后短短的不到十年里,世界上已经出现了数次流感瘟疫,但是它们的严重性和死亡人数已经比20世纪时大大降低。2002年11月,在中国广东省 出现了首例非典型性肺炎感染者。这种高危险性的肺炎简称萨斯,由于在2003年上半年在中国大部分地区以极快的速度广泛传播,加上中国有关卫生部门和政府 机构在疫情出现的初期采取隐瞒的做法,导致了许多人的恐慌。据统计,全世界一共有8000人左右感染萨斯病毒,死亡人数约为800人,其中中国有将近 350人。

2003年,H5N1型高致病性禽流感病毒由越南蔓延到东南亚其它国家,中国也受到了一定程度的波及。禽流感病毒至今一共造成250多人死亡。与这次在墨西哥爆发的猪流感不同,禽流感病毒只能通过禽类向人类传播,而不会在人与人之间直接传播。

几乎年年都有不同程度的流感疫情出现。正是因为流感病毒变异的速度十分迅猛,所以也对医学界研制治疗药物和疫苗提出了很大的挑战。据世界卫生组织公布,全球每年都有300万到500万人感染严重的流感,其中大约有25万到50万人因流感而死亡。

作者:雨涵

责编:乐然

2009年4月24日 星期五

Milk protein clue to big babies

Milk protein clue to big babies

Baby being bottle-fed
How babies are fed is the subject of much debate

Breast milk has less protein than formula, which could be why bottle-fed babies grow faster, a study suggests.

There has been concern that formula-fed babies, who tend to be bigger, are "programmed" to store fat and so have a higher risk of childhood obesity.

The international study of 1,000 babies, published in the American Journal of Clinical Nutrition, suggests protein levels in formula should fall.

But UK manufacturers said action had already been taken to cut levels.

Measures

The study was carried out in Belgium, Italy, Germany, Poland and Spain on babies born between 2002 and 2004.

Parents were recruited to take part in the first few weeks of their babies' lives.

A third were given a low protein content formula milk (around 2g per 100kcal), a third had a formula with a higher level of protein (3-4g per 10kcal), while the rest were breast-fed during their first year.

Limiting the protein content of infant and follow-on formula can normalise early growth and might contribute greatly to reducing the long-term risk of childhood overweight and obesity
Professor Berthold Koletzko, Study author

To qualify as breast-fed, babies had to be either exclusively given breast milk, or have a maximum of three bottles per week.

The infants were all then followed up to the age of two with regular weight, height and body mass index measurements taken.

At the age of two, there was no difference in height between the groups, but the high protein group were the heaviest.

The researchers suggest lower protein intakes in infancy might protect against later obesity.

The children are being followed up further to see whether those given the lower protein formulas have a reduced risk of obesity later on.

Changes needed?

Professor Berthold Koletzko, from the University of Munich, Germany, and who led the study, said: "These results from the EU Childhood Obesity Programme underline the importance of promoting and supporting breastfeeding because of the long-term benefits it brings.

"They also highlight the importance of the continual development and improvement in the composition of infant formula.

"Limiting the protein content of infant and follow-on formula can normalise early growth and might contribute greatly to reducing the long-term risk of childhood overweight and obesity."

But writing in the American Journal of Nutrition, Dr Satish Kalhan of the Case Western Reserve University in Cleveland, US, said: "On the basis of these data, should we consider prescribing low protein formula to infants?

"The answer most likely is a categorical no."

A spokesman for the UK's Infant and Dietetic Food Association said companies had already reduced protein levels to well below those mentioned in the study.

She added: "The scientific evidence reviewing the role of infant formula in the development of obesity in later life is unclear.

"Most studies in this area are short-term and very few look at the long-term effect into adulthood."

But she added: "Clearly further research is required and this is an area we follow closely to ensure that the product we represent are based on generally accepted scientific evidence."

New infant growth charts, to be introduced in the UK this summer, have been changed so they relate more closely to the growth patterns of breast-fed babies.

Existing charts are based on a 1970s study into the growth patterns of formula-fed babies, and many breast-fed babies fall short - often causing concern to their parents and to health visitors.