2009年2月22日 星期日

‘Deep Web’

Exploring a ‘Deep Web’ That Google Can’t Grasp

Jeffrey D. Allred for The New York Times

At the University of Utah, Prof. Juliana Freire is working on DeepPeep, an ambitious effort to index every public database online. by ALEX WRIGHT

Published: February 22, 2009

One day last summer, Google’s search engine trundled quietly past a milestone. It added the one trillionth address to the list of Web pages it knows about. But as impossibly big as that number may seem, it represents only a fraction of the entire Web.

Beyond those trillion pages lies an even vaster Web of hidden data: financial information, shopping catalogs, flight schedules, medical research and all kinds of other material stored in databases that remain largely invisible to search engines.

The challenges that the major search engines face in penetrating this so-called Deep Web go a long way toward explaining why they still can’t provide satisfying answers to questions like “What’s the best fare from New York to London next Thursday?” or “When will the Yankees play the Red Sox this year?” The answers are readily available — if only the search engines knew how to find them.

Now a new breed of technologies is taking shape that will extend the reach of search engines into the Web’s hidden corners. When that happens, it will do more than just improve the quality of search results — it may ultimately reshape the way many companies do business online.

Search engines rely on programs known as crawlers (or spiders) that gather information by following the trails of hyperlinks that tie the Web together. While that approach works well for the pages that make up the surface Web, these programs have a harder time penetrating databases that are set up to respond to typed queries.

“The crawlable Web is the tip of the iceberg,” says Anand Rajaraman, co-founder of Kosmix (www.kosmix.com), a Deep Web search start-up whose investors include Jeffrey P. Bezos, chief executive of Amazon.com. Kosmix has developed software that matches searches with the databases most likely to yield relevant information, then returns an overview of the topic drawn from multiple sources.

“Most search engines try to help you find a needle in a haystack,” Mr. Rajaraman said, “but what we’re trying to do is help you explore the haystack.”

That haystack is infinitely large. With millions of databases connected to the Web, and endless possible permutations of search terms, there is simply no way for any search engine — no matter how powerful — to sift through every possible combination of data on the fly.

To extract meaningful data from the Deep Web, search engines have to analyze users’ search terms and figure out how to broker those queries to particular databases. For example, if a user types in “Rembrandt,” the search engine needs to know which databases are most likely to contain information about fine art (like, say, museum catalogs or auction houses), and what kinds of queries those databases will accept.

That approach may sound straightforward in theory, but in practice the vast variety of database structures and possible search terms poses a thorny computational challenge.

“This is the most interesting data integration problem imaginable,” says Alon Halevy, a former computer science professor at the University of Washington who is now leading a team at Google that is trying to solve the Deep Web conundrum.

Google’s Deep Web search strategy involves sending out a program to analyze the contents of every database it encounters. For example, if the search engine finds a page with a form related to fine art, it starts guessing likely search terms — “Rembrandt,” “Picasso,” “Vermeer” and so on — until one of those terms returns a match. The search engine then analyzes the results and develops a predictive model of what the database contains.

In a similar vein, Prof. Juliana Freire at the University of Utah is working on an ambitious project called DeepPeep (www.deeppeep.org) that eventually aims to crawl and index every database on the public Web. Extracting the contents of so many far-flung data sets requires a sophisticated kind of computational guessing game.

“The naïve way would be to query all the words in the dictionary,” Ms. Freire said. Instead, DeepPeep starts by posing a small number of sample queries, “so we can then use that to build up our understanding of the databases and choose which words to search.”

Based on that analysis, the program then fires off automated search terms in an effort to dislodge as much data as possible. Ms. Freire claims that her approach retrieves better than 90 percent of the content stored in any given database. Ms. Freire’s work has recently attracted overtures from one of the major search engine companies.

As the major search engines start to experiment with incorporating Deep Web content into their search results, they must figure out how to present different kinds of data without overcomplicating their pages. This poses a particular quandary for Google, which has long resisted the temptation to make significant changes to its tried-and-true search results format.

“Google faces a real challenge,” said Chris Sherman, executive editor of the Web site Search Engine Land. “They want to make the experience better, but they have to be supercautious with making changes for fear of alienating their users.”

Beyond the realm of consumer searches, Deep Web technologies may eventually let businesses use data in new ways. For example, a health site could cross-reference data from pharmaceutical companies with the latest findings from medical researchers, or a local news site could extend its coverage by letting users tap into public records stored in government databases.

This level of data integration could eventually point the way toward something like the Semantic Web, the much-promoted — but so far unrealized — vision of a Web of interconnected data. Deep Web technologies hold the promise of achieving similar benefits at a much lower cost, by automating the process of analyzing database structures and cross-referencing the results.

“The huge thing is the ability to connect disparate data sources,” said Mike Bergman, a computer scientist and consultant who is credited with coining the term Deep Web. Mr. Bergman said the long-term impact of Deep Web search had more to do with transforming business than with satisfying the whims of Web surfers.

2009年2月20日 星期五

Breast cancer biology 'changing'

Breast cancer biology 'changing'

By Emma Wilkinson
Health reporter, BBC News

Breast cancer cells
Breast cancer is the commonest cancer in UK women

Lifestyle changes and screening have shifted the type of breast cancers women are diagnosed with over the past couple of decades, research suggests.

Women are now more likely to have hormone-dependent, slow-growing tumours, a comparison of tissue samples from the 1980s and 1990s shows.

The Scottish researchers also found improved survival over time, the British Journal of Cancer reported.

More than 40,000 women are diagnosed with breast cancer in the UK annually.

Previous studies have suggested that breast cancers may be more commonly hormone-dependent than in the past.

It's plausible that lifestyle changes could be influencing the types of breast cancers that women are developing but we will need much larger studies to find out whether this trend is real
Dr Alison Ross, Cancer Research UK

Specifically it is thought that oestrogen-receptor positive cancers may be on the rise.

It is these tumours which respond well to hormone therapy, such as tamoxifen which prevents the disease coming back.

But it has not been clear that numbers were actually on the rise as the ability to detect these types of tumours in the lab may have improved in recent years.

In the latest study, researchers re-examined actual tissue samples - 420 from between 1984 and 1986 and 653 from 1996 to 1997 - saved by two large hospitals in Glasgow.

Those diagnosed in the earlier time period had all presented with symptoms of cancer because screening by mammography had not yet been introduced.

The proportion of cancers which were oestrogen-receptor positive changed significantly from 64.2% to 71.5% over the 10-year period.

And more cancers were diagnosed as grade one - slow-growing tumours, with a decline in the number of grade three - fast-growing tumours.

There was no change over time in the proportion of progesterone or Her-2 positive cancers

Lifestyle

It could be that screening is detecting more oestrogen-receptor positive cancers because they are slow-growing and may be detected before symptoms appear.

But another explanation could be changes in lifestyle factors which increase the risk of hormone-dependent tumours, such as women having babies at an older age, obesity after menopause and use of hormone replacement therapy.

The researchers, led by Dr Sylvia Brown at Crosshouse Hospital in Ayrshire wrote: "There is evidence that the percentage of all children being born to mothers aged 35 years and over is increasing in Scotland and that means BMI and prevalence of obesity are increasing."

She added that if there is a true increase in the proportion of these tumours it has implications for treatment decisions as many clinical trials were carried out in previous decades.

Dr Alison Ross, Cancer Research UK's senior science information officer, said: "It's plausible that lifestyle changes could be influencing the types of breast cancers that women are developing but we will need much larger studies to find out whether this trend is real.

"And it's also not clear whether these results reflect a shift in breast cancer biology or indicate that screening is better at detecting certain cancers.

"If the trend identified in this interesting study is confirmed and continues, it could have an impact on the way doctors apply results from breast cancer studies done decades ago to the treatments in use today."