A major medical breakthrough suggests daily cholesterol pills may soon be a thing of the past. Scientists used CRISPR gene-editing technology to switch off a single gene in the liver responsible for producing excess cholesterol. With just one injection, the body’s cholesterol regulation was permanently altered.
In early human trials, LDL (“bad”) cholesterol levels dropped by around 50%, while triglycerides fell by more than 55%. Unlike statins or other medications that require daily use, this treatment appears to be long-lasting, potentially eliminating the need for lifelong drug therapy. The change happens at the genetic level inside liver cells.
This approach targets the root cause of high cholesterol rather than managing symptoms. By editing the gene that drives overproduction, the liver naturally maintains healthier lipid levels without ongoing intervention. Researchers believe this could dramatically reduce heart attack and stroke risk in high-risk patients.
The implications extend far beyond cholesterol. Similar gene-editing strategies could one day be applied to conditions like hypertension, type 2 diabetes, and inherited cardiovascular disorders. Medicine may be shifting from chronic treatment models toward permanent biological fixes.
While long-term safety and wider trials are still underway, experts say this marks a turning point in preventive medicine. A future where one-time therapies replace decades of daily pills could redefine healthcare, costs, and how diseases are treated at their source.
HC回憶錄： 等候線理論； 英國導師課-考試；校園洗衣機房，AI；台北台中交通系統模擬； AI 與性感.......NVIDIA has acquired SchedMD , the company behind Slurm, the widely used open-source workload manager for HPC and AI clusters.
risqué (of jokes or stories) slightly rude or shocking, especially because about sex
"The Levi's Launderette advert was a significant cultural flashpoint," Dr Hannah Hamad, reader in media and communication at Cardiff University, tells the BBC. Beyond its effect on our buying patterns, it was, she says, "symptomatic of cultural re-evaluations of masculinity… that placed emphasis on the sexual desire of women, via the sexual objectification of men".
It was such an iconic ad at the time and probably one of the first times the script had been flipped around to have a female gaze on a male body – Ali Hanan
Ali Hanan, founder of inclusive marketing consultancy Creative Equals, agrees. "It was such an iconic ad at the time and probably one of the first times the script had been flipped around to have a female gaze on a male body," she tells the BBC. The older, less progressive script was used everywhere, from the suggestive 1970s Cadbury's Flake commercials to the controversial Calvin Klein campaign featuring a 15-year-old Brooke Shields whispering the tagline, "You want to know what comes between me and my Calvins? Nothing." In the early '80s, women were still the object of the commercial, rather than shaping its viewpoint.
The advert changed the fortunes of Levi's – and also caused a sharp rise in the sales of boxer shorts (Credit: 'Launderette' Levi's advertisement, Bartle Bogle Hegarty)
The Launderette ad was different. "It came from a female perspective," says Hanan, and was written by Barbara Nokes, one of eight founding partners of global advertising agency Bartle Bogle Hegarty (BBH). Nokes's role, says Hanan, "has got quite lost in the story of that ad". The advert reflected a wider "rebellious culture", Hanan believes, that created the conditions for change. "In the '80s, it was all about innovation and creativity," she says. "There were a lot of old ways of thinking and working that were upended during that time."
AI Overview
A workload manager for HPC (High-Performance Computing) is software that schedules and allocates resources (like CPUs, GPUs, memory) to parallel jobs on large clusters, ensuring efficient use and fair access, with Slurm Workload Manager being the dominant open-source standard used in most supercomputers for complex simulations and AI/ML tasks, coordinating job submission, execution, and monitoring.
Key Functions of HPC Workload ManagersResource Allocation: Grants exclusive or shared access to compute nodes for specific durations. Job Scheduling: Queues and manages thousands of jobs, optimizing for fairness, priority, and resource availability. Execution & Monitoring: Starts, monitors, and manages the execution of parallel applications across allocated nodes. Scalability: Designed to handle massive clusters with hundreds of thousands of cores.
Top HPC Workload ManagersSlurm Workload Manager (Simple Linux Utility for Resource Management):Dominant: Used by over 50% of the TOP500 supercomputers. Open-Source: Free, highly scalable, and supports complex policies. Versatile: Excellent for traditional HPC, AI, and Machine Learning workloads, managing GPU resources effectively. Acquisition: Recently acquired by NVIDIA, ensuring continued open-source support.
Other/Related ToolsPBS Professional (Portable Batch System): A commercial alternative, also widely used in HPC. LS-DYNA/ANSYS/etc. Integrations: Specialized tools often integrate with workload managers like Slurm to manage their complex simulations.
How it Works (Simplified)User Submits Job: A researcher submits a job script with resource requests (e.g., "2 nodes, 4 GPUs, 2 hours") via the command line (CLI). Slurm Queues Job: Slurm places the job in a queue. Scheduler Finds Resources: When resources are free, Slurm allocates nodes to the job. Job Runs: The job executes on the allocated nodes, potentially across many cores/GPUs. Results Collected: Data and results are gathered upon completion.
Overview - Slurm Workload Manager - SchedMDSlurm is an open source, fault-tolerant, and highly scalable cluster management and job scheduling system for large and small Linu... Slurm Documentation
Workload Management & Orchestration Series: Slurm ... - WWTJun 15, 2025 — Slurm Workload Manager: Scheduling for HPC environments Slurm Workload Manager is a highly scalable, open-source job s... World Wide Technology | WWT
Slurm Workload Manager: The go-to scheduler for HPC and AI ...Jul 31, 2025 — Slurm Workload Manager: The go-to scheduler for HPC and AI workloads. Slurm Workload Manager is a cornerstone of high- Nebius
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NVIDIA has acquired SchedMD , the company behind Slurm, the widely used open-source workload manager for HPC and AI clusters.
The move aims to simplify how large-scale AI tasks are scheduled and managed, while maintaining NVIDIA’s approach to working with vendor-neutral, open-source software.
NVIDIA said Slurm will remain open source, with SchedMD’s team continuing development, support and training for existing users.
The companies have collaborated for over a decade on AI and supercomputing infrastructure.
Jan 28, 2019 - A chiplet is an integrated circuit block that is part of a chip that consists of multiple such chiplets. In such chips, a system is subdivided into ...
Nov 6, 2018 - The new approach comes with a snappy name: chiplets. You can think of them as something like high-tech Lego blocks. Instead of carving new ...
1 day ago - Ramune Nagisetty is helping Intel establish its place in a new industry ecosystem centered on chiplets.
Chiplets are a way to make systems that perform a lot like they are all one chip, despite actually being composed of several smaller chips. They’re widely seen as one part of the computing industry’s plan to keep systems performing better and better despite the fact that traditional Moore’s Law scaling is nearing its end. Proponents say the benefits will include more easily-specialized systems and higher yield, among other things. But more importantly, they might lead to a big shift in the fabless semiconductor industry, where the targeted end-product might become a small, specialized chiplet meant to be combined in the same package with both a general purpose processor and many others specialty chiplets. Ramune Nagisetty, a principal engineer and director of process and product integration at Intel’s technology development group in Oregon, has been working to help develop an industry-wide chiplet ecosystem. She told IEEE Spectrum about that and the Intel technologies involved on 21 March 2019.
chiplet. A future semiconductor technology from Palo Alto Research Center (PARC), a subsidiary of Xerox, that ties together minuscule circuits no larger than a ...
